Losing in fantasy football stinks. I know a good amount about football and I think I always make the right moves but I still lose, why is this? The simple answer is just plain bad luck. There is no way to avoid luck in fantasy football. I have played quarterbacks who are going against one of the worst defenses in the league and they end up doing nothing. Then I bench them when they play against a great defense and they end up with 300 yards and 3 touchdowns.
These types of things cannot be predicted, and as a fantasy football player you just need to do whatever to make your odds of winning the greatest. I consider it alot of poker. The best poker player in a tournament will lose quite often to lesser players, and that is just because of dumb luck. They do have the best chances of winning though because of their strong skills and good decision making.
In a short period of time with fantasy football you could win every game or lose every single one no matter how good or bad your decisions are. If you are a strong player, over time statistics will run their course and you will win in the long run.