Knowing your scoring system is probably the most important way of being successful in a fantasy football league. Is your league a touch down driven or a yards gained driven league. By standard it is usually fairly balanced, but it my case it was not. Touch downs were only worth 4 points for all positions, so yards gained was a big source of your weekly points. Also there are bonus' in my league if your player gets a certain amount of yards. This bonus can really be the difference between a win and a lost.
The way to take this into consideration when drafting is you need to look for players that match your point system. Running backs who get lots of touch downs but only because they run it in from the goal line may not be that valuable to you. You want the player who will run 100 yards a week but may only get 1 touchdown.