Running backs are usually the highest scoring players in fantasy football. Conventional wisdom for drafting usually says to get a running back in the 1st and 2nd round. I tend to agree with this to a point, because it depends alot on your scoring system. For me I had the 6th pick, so I was in a good position to pick Andre Johnson 1st (the best wide receiver). It came down to the wire but I ended up not selecting him, I choose Michael Turner instead. Turner had a great year last year but was injured, he was on pace for some incredible numbers. I heard he was completely healthy so I went with him.
First round picks are so important. You must get good production out of your 1st round guy or you'll be in big trouble in my opinion. Its obviously possible to win a league without even a 1st round pick, but highly unlikely
Finally my 2nd round pick was Mendenhall of Pittsburg, with I thought was a good value pick for 2nd round. Hoping he does well.